Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, This compound has unique chemical properties. The synthetic route is as follows., 1080-74-6
A solution of 5′-bromo-3,4′-dihexyl-[2,2′-bithiophene]-5-carbaldehyde (1.39 g, 3.14 mmol), denatured ethanol (75 cm3), pyridine (5 drops) and 3- (dicyanomethylidene)indan-1-one (0.61 g, 3.1 mmol) was stirred at 23 C for 20 minutes. Additional denatured ethanol (50 cm3) was added and the suspension heated at 80 C for 1 hour. The suspension was cooled to 23 C and the solid collected by filtration. The solid was washed with ethanol (50 cm3) then methanol (50 cm3) to give intermediate 5 (1.73 g, 89%) as a dark solid.1H NMR (400 MHz, CD2Cl2) 8.75 (1H, s), 8.62 – 8.70 (1H, m), 7.87 – 7.96 (1H, m), 7.73 – 7.86 (2H, m), 7.64 (1H, s), 7.23 (1H, s), 2.72 – 2.82 (2H, m), 2.60 – 2.68 (2H, m), 1.62 – 1.77 (4H, m), 1.32 – 1.51 (12H, m), 0.86 – 1.02 (6H, m).13C NMR (100 MHz, CD2Cl2) 188.1, 160.2, 147.6, 147.0, 143.6, 140.9, 139.9, 137.2, 136.9, 135.1, 134.6, 134.5, 134.3, 128.9, 125.2, 123.7, 122.9, 114.6, 114.5, 112.6, 69.9, 31.6, 31.6, 30.0, 29.6, 29.5, 29.2, 29.1, 28.9, 22.6, 13.9, 13.8.
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Reference:
Patent; MERCK PATENT GMBH; MITCHELL, William; WANG, Changsheng; D’LAVARI, Mansoor; (163 pag.)WO2020/48939; (2020); A1;,
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