127946-77-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
1-azanylcyclopropane-1-carbonitrile hydrochloride (671.53 mg, 5.66 mmol), (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(3-pyridyl)propanoic acid (2 g, 5.15 mmol) and HATU (2.15 g, 5.66 mmol) were suspended in DMF (15 mL). DIPEA (2.63 mL, 15.45 mmol) was added and mixture stirred for 16H at room temperature. The mixture was diluted with EtOAc and washed with water and brine. Organic layer was separated, dried (Na2SO4), filtered and concentrated to get a crude which was purified by column chromatography. Biotage SNAP KP-SiO2 100 g; eluent: solvent A: petroleum ether; solvent B: EtOAc.
The synthetic route of 1-Amino-1-cyclopropanecarbonitrile hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nizi, Emanuela; Sferrazza, Alessio; Fabbrini, Danilo; Nardi, Valentina; Andreini, Matteo; Graziani, Rita; Gennari, Nadia; Bresciani, Alberto; Paonessa, Giacomo; Harper, Steven; Bioorganic and Medicinal Chemistry Letters; vol. 28; 9; (2018); p. 1540 – 1544;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts