114897-91-5, A common heterocyclic compound, 114897-91-5, name is 2-(4-Bromo-2-fluorophenyl)acetonitrile, molecular formula is C8H5BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(11-2) According to a method similar to Example (8-1), from (4-bromo-2-fluorophenyl)acetonitrile (3.0 g, 14 mmol) obtained in Example (11-1) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (3.45 g, 14 mmol), (3-fluoro-4′-hydroxy-1,1′-biphenyl-4-yl)acetonitrile was obtained as a colorless solid (2.9 g, yield: 91%). 1H-NMR (400MHz, MeOH-d4): delta 7.50-7.34 (5H, m), 6.87 (2H, d, J=8.8Hz), 3.92 (2H, s).
The synthetic route of 114897-91-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Daiichi Sankyo Company, Limited; EP1806332; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts