In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 127946-77-4
To a 100 mL two-neck flask were added 1-((tert-butylcarbonate)amino)cyclohexanecarboxylic acid (2.43 g, 10 mmol), 1-amino-1-cyclopropanecarbonitrile hydrochloride (1.42 g, 12 mmol) and DMF (15 mL). To the mixture were added HATU (5.32 g, 14 mmol) and ethyldiisopropylamine (8.8 mL, 50 mmol) at 0C under nitrogen protection. The mixture was stirred for 1.0 h at 0 C under nitrogen protection. To the reaction mixture was added saturated aqueous sodium chloride (30 mL), and the resulting mixture was extracted with ethyl acetate (30 mL*3). The combined organic layer was washed with saturated brine (30 mL*3), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to give light yellow oil (2.82 g, 91%). This crude product was used in next step without further purification.
The synthetic route of 127946-77-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; WANG, Xiaojun; ZHOU, Pingjian; YANG, Chuanwen; HUANG, Changwei; XIONG, Shaohui; ZHANG, Yingjun; ZHANG, Jiancun; (139 pag.)EP3342765; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts