Synthetic Route of 2032-34-0, These common heterocyclic compound, 2032-34-0, name is 3,3-Diethoxypropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 3, 3-diethoxypropane-nitrile (283.80 g, 1.98 moles) and methyl formate (148.80 g, 2.48 moles) in anhydrous THF (1.1 L) at [10C] was added 1.0 M potassium [TERT-BUTOXIDE] in THF (2.2 L, 2.2 moles). The temperature was maintained in the range of [10C] to [15 C] throughout the 45 minute addition. Following the addition, the resulting slurry was stirred for 2 hours at ambient temperature. Hexane (400 mL) was then added and stirring was continued for another 20 min. The slurry was filtered and the cake washed with [1/1] hexanes/THF and dried overnight at [60C] in a vacuum oven to yield 302.5 grams (73.0%) of the above compound P-5A as a pale tan [POWDER.’H-NMR] (CD30D) was consistent with the desired structure.
The synthetic route of 2032-34-0 has been constantly updated, and we look forward to future research findings.