These common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3,4-Diaminobenzonitrile
A 0.03 mol% Lewis acid-base bifunctional catalyst I (where Rf = CF3; R1, R2, R3, R4, R5, R6 = F) was added to a 100 mL single-mouth flask.0.2 mol of 4-fluoro-benzaldehyde (R7=4-F-C6H4), 0.1 mol of p-cyano o-phenylenediamine (R9=CN; R8, R10, R11=H), 15 mL of toluene, reacting at 25C Stir for 5 hours,TLC followed the reaction until the reaction was complete. The reaction results showed that the yield of product II (R7=4-F-C6H4; R9=CN; R8, R10, R11=H) was 94%; after repeated use of the catalyst system for 10 times, the catalytic performance did not decrease.
The synthetic route of 3,4-Diaminobenzonitrile has been constantly updated, and we look forward to future research findings.