In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22972-63-0 as follows. category: nitriles-buliding-blocks
A solution of DIBAL ([1 M] in toluene) (1 60.9 ml_, 160.9 mmol, 2.5 eq) was added dropwise to a stirred solution of 2-(3,5-Dimethoxy-phenyl)-2-methyl-propionitrile (13.2 g, 64.36 mmol, 1 eq) in dry CH2CI2 (320 ml_) under nitrogen at -78 SC. The reaction mixture was stirred at -78 SC for 1 h. An aqueous solution of potassium sodium tartrate (10% solution in water) was added dropwise and the reaction mixture was warmed to room temperature and stirred vigorously overnight. The solid was filtered through celite and rinsed with CH2CI2, the product was extracted with CH2CI2. The combined organic layers were washed with brine and water, dried over anhydrous MgSC , filtered and the solvent was removed under reduced pressure. The product was purified by chromatography on silica gel (heptane/EtOAc, from 100:0 to 80:20). The desired fractions were collected and concentrated to afford the title product as a colorless oil. (1 1 .6 g, 86.5 %). 1 H NMR (300 MHz, CDC ) d 9.46 (s, 1 H), 6.40 (s, 3H), 3.79 (s, 6H), 1 .43 (s, 6H). LC-MS (ESI+): 209.1 (M+H+); R.T. : 1 .388 min. (HPLC Method E).
According to the analysis of related databases, 22972-63-0, the application of this compound in the production field has become more and more popular.