These common heterocyclic compound, 621-50-1, name is 2-(3-Nitrophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks
[0308] To the mixture of solution of 3-nitrophenylacetonitrile (16.2g, 0. lmol) and ion powder (56g, lmol) in ethanol (160ml) and water (40ml), added hydrochloride (25ml, 6N), heated to reflux for 4 hours. Filtered through celite, concentrated, extracted with EtOAc, washed with water and brine, dried over sodium sulfate.Removed solvent, got crude product as oil.
The synthetic route of 2-(3-Nitrophenyl)acetonitrile has been constantly updated, and we look forward to future research findings.