Synthetic Route of 27387-23-1,Some common heterocyclic compound, 27387-23-1, name is 2-(2-Bromo-5-methoxyphenyl)acetonitrile, molecular formula is C9H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2: (2-Bromo-5-hydroxy-phenyl)-acetonitrile[00447] To (2-bromo-5-methoxy-phenyl)-acetonitrile (2.6g, 11.5mmol) in CH2Cl2 (2OmL) at O0C under N2 was added boron tribromide (IM in CH2Cl2; 25.4mL, 25.4mmol). The mixture was stirred for 15 minutes at O0C, and at room temperature overnight. After a work-up with H2O and CH2Cl2, the crude material was purified by silica gel chromatography to give the desired product as a white SoUd (1.5g).
The synthetic route of 27387-23-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMIRA PHARMACEUTICALS, INC.; WO2009/102893; (2009); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts