The chemical industry reduces the impact on the environment during synthesis 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, I believe this compound will play a more active role in future production and life. 194853-86-6
4-Fluoro-2-trifluoromethyl-benzonitrile (1.20g) was dissolved in THF (20MOI) and 3- PIPERIDIN-1-YL-PROPAN-1-OL (0. 91MI) was added. The reaction was cooled to OOC and potassium HEXAMETHYLDISILAZIDE (0.5M solution in toluene; 12. 72ML) was added dropwise. The reaction was stirred at rt overnight, then diluted with ethyl acetate (50ML) and partitioned with aqueous 1 N HCI (50ML). The aqueous layer was washed with ethyl acetate (50ML), then basified to pH 8.0 with sodium hydrogen carbonate and extracted with ethyl acetate (3X75ML). The combined organic extracts were dried (MgSO4) and evaporated to give the title compound (D14) as a clear oil which crystallised on standing (0.80g).
The chemical industry reduces the impact on the environment during synthesis 194853-86-6. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/37800; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts