Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36282-26-5, name is 2-Bromo-4-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Bromo-4-fluorobenzonitrile
To a mixture of 15 (0.100 g, 0.43 mmol) and NaH (15.5 mg, 0.65 mmol) in DMF (8 mL) was added 2-bromo-4-fluorobenzonitrile (86 mg, 0.43 mmol) and heated at 90 C for 5 h. The reaction mixture was concentrated under reduced pressure and the residue chromatographed (hexane/EtOAc, 10:1-10:2) to give 0.162 g (91%) of 16 as a white solid. 1H NMR (CDCl3) delta 7.97 (d, J = 2.1 Hz, 1H), 7.85 (d, J = 8.4 Hz, 1H), 7.63 (dd, J = 8.4, 2.1 Hz, 1H), 2.89 (s, 2H), 2.51 (s, 2H), 1.16 (s, 6H); MS (ESI): m/z 410.0/412.0 [M-H]-.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 36282-26-5.
Reference:
Article; Taldone, Tony; Zatorska, Danuta; Patel, Pallav D.; Zong, Hongliang; Rodina, Anna; Ahn, James H.; Moulick, Kamalika; Guzman, Monica L.; Chiosis, Gabriela; Bioorganic and Medicinal Chemistry; vol. 19; 8; (2011); p. 2603 – 2614;,
Nitrile – Wikipedia,
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