Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 874-97-5, name is 3-Cyanobenzyl alcohol, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Cyanobenzyl alcohol
Add p-toluene sulphonic acid (2.11 g, 12.2 mmol) to a solution of 3- hydroxymethyl-benzonitrile( 16.30 g, 122.4 mmol) and 3,4-dihydro-2H-pyran (51.5 g, 612 mmol) in dicliloromethane (500 ml) and stir. After 90 minutes, pour reaction into saturated sodium bicarbonate, remove organics, dry with sodium sulfate, filter and concentrate to give a dark brown oil. Purify the residue by flash chromatography eluting with a gradient of 10-15% ethyl acetate :hexanes to yield the title product as a clear oil (16.20 g, 61%): 1H NMR (CDCl3) delta 1.53-1.91 (m, 6H), 3.56 (m, IH)5 3.88 (m, IH), 4.53 (d, IH), 4.72 (t, IH), 4.81 (d, IH), 7.45 (t, IH), 7.58 (m, 2H), 7.69 (s, IH)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ELI LILLY AND COMPANY; WO2006/57860; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts