Adding a certain compound to certain chemical reactions, such as: 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4592-94-3, COA of Formula: C9H6BrNO
Example 36 Preparation of 3-(4-bromophenyl)-3-hydroxypropanenitrile A suspension of 4-bromobenzoylacetonitrile (500 mg) in ethanol (5 mL) and acetic acid (300 muL) was heated with sodium cyanoborohydride (280 mg) using an 80 C. hot plate for 2 hours. After cooling to ambient temperature, the mixture was diluted with water and concentrated to a syrup, which was diluted with ethyl acetate and washed with water, sat. NaHCO3, and brine. The extract was dried with mgSO4, filtered, and evaporated to provide 510 mg of a cloudy oil, which was filtered through silica gel using 1:1 ethyl acetate/hexane to provide the product (496 mg) as a thick oil.
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Reference:
Patent; ProLynx LLC; Santi, Daniel V.; Ashley, Gary W.; (80 pag.)US9387254; (2016); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts