Electric Literature of 55490-87-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55490-87-4, name is 2-(Anthracen-9-ylmethylene)malononitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: The mixture of beta-cyanostyrenes 1 (1.0 mmol) and PIDA 2a (386 mg, 1.2 equiv) in acetonitrile and water (1:1) (5 mL) was irradiated in ultrasonic bath (Power dissipation as 50 W and frequency of 40 kHz) at room temperature for 30-60 min. The course of reaction was monitored by TLC. After completion of reaction, water (5 mL) was added to the reaction mixture and extracted with dichloromethane (3 X 5 mL). The combined organic layer was dried over anhydrous sodium sulphate and concentrated under vacuum. The crude products were purified by column chromatography on silica gel using EtOAc-hexane (1:49) and isolated products were characterized as beta-cyanoepoxides 3 by their spectroscopic analysis.
The synthetic route of 2-(Anthracen-9-ylmethylene)malononitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Singh, Fateh V.; Mangaonkar, Saeesh R.; Kole, Priyanka B.; Synthetic Communications; vol. 48; 17; (2018); p. 2169 – 2176;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts