Application of 57381-51-8,Some common heterocyclic compound, 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, molecular formula is C7H3ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To commercially available 2-fluoro-4-chlorobenzonitrile 15a (2 g,12.8 mmol) dimethylamine (4equiv., 3.5 ml) was added and the solution was heated in closed vessel at 80C overnight. The reaction was evaporated and the residue was dissolved in AcOEt and washed with water and brine. The residue was purified by chromatographic column using EtOAc 1 / petroleum ether 9 as eluant obtaining 1.95 g of a transparent oil. Yield = 87% ‘HNMR (DMSO, 200 MHz) delta 3.01 (6H, s), 6.91 (1H, dd, J = 8.4 Hz, J’ = 2 Hz), 7.02 (1H, d, J = 2 Hz), 7.60 (1H, d, J = 8.4 Hz)
The synthetic route of 57381-51-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts