Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 628-20-6, name is 4-Chlorobutyronitrile, A new synthetic method of this compound is introduced below., COA of Formula: C4H6ClN
A solution of 2- (1-methyl-1H-pyrazol-4-yl) -7- (piperidin-4-yl) -5 – ((2- (trimethylsilyl) ethoxy) -5H-pyrrolo [2,3-b] pyrazine (130 mg, 0.31 mmol)Of acetonitrile (8 mL)Potassium carbonate (110 mg, 0.79 mmol) was added sequentially to the solution,Potassium iodide (10 mg, 0.06 mmol) and4-chlorobutyronitrile (0.05 mL, 0.5 mmol)The reaction was heated at 50 C for 24 hours,Diluted with water (20 mL), extracted with dichloromethane (20 mL x 3), dried over anhydrous sodium sulfate and concentrated column chromatography (dichloromethane / methanol (v / v) = 8/1)120 mg of a yellow oil was obtained in a yield of 79.40%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Huang Jiuzhong; Zheng Changchun; Zhang Yingjun; Ouyang Luo; Mao Hongfen; Nie Biao; Xu Juan; Chen Hongfen; (137 pag.)CN106336413; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts