Adding a certain compound to certain chemical reactions, such as: 87376-25-8, name is 2-Amino-4-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87376-25-8, Product Details of 87376-25-8
General procedure: A mixture of 2-aminobenzonitrile 1a (0.3 mmol), trans-beta-nitrostyrene 2a (0.3 mmol), and CuBr (0.03mmol) in DMSO (2 mL) was stirred at 120 C for 8 hours till almost completed conversion of thesubstrates by TLC analysis. Then 30% NaCl solution (50 mL) was added to the mixture, which was thenextracted with EtOAc three times (3×50 mL). The extract was dried over anhydrous Na2SO4 andconcentrated in vacuo. The crude product was purified by column chromatography on silica gel (eluent:petroleumether/EtOAc) to afford the product 3a (70.8 mg, 89%) as a yellow solid.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Cai, Qun; Chen, Hui; Liao, Meng; Liu, Yi; Peng, Na; Sheng, Hui-Yang; Yang, Mian; Chemistry Letters; vol. 49; 5; (2020); p. 526 – 529;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts