Adding a certain compound to certain chemical reactions, such as: 34916-10-4, name is 4-Oxo-cyclohexanecarbonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34916-10-4, Recommanded Product: 4-Oxo-cyclohexanecarbonitrile
To a solution of 4-cyanocyclohexanone (200 mg, 1 .626 mmol) and CH3NH2 (2M in THE) (0.8 mL, 1.626 mmol) in THF:CH2CI2 (1:1) (4.0 mL) at 0C was added NaBH(OAc)3 (689 mg, 3.252 mmol) and the resulting mixture was stirred at rt for 48 h. Subsquently, the solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate, washed with water, brine, dried over Na2SO4 and concentrated to afford 200 mg (89%) of 4-(methylamino)cyclohexanecarbonitrile as a white solid. NMR (400 MHz, DMSO-d6) 2.91 & 2.61 (two signals, 1 H) 2.23-2.24 (m, 3 H) 1.02 – 1.99 (m, 9 H); ELSD/MS (Method 3) (m/z): [M÷H] 139.06.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Oxo-cyclohexanecarbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; KONDREDDI, Ravinder Reddy; LEONG, Seh Yong; MISHRA, Pranab Kumar; MOREAU, Robert Joseph; ROLAND, Jason Thomas; SIM, Wei Lin Sandra; SIMON, Oliver; TAN, Liying Jocelyn; YEUNG, Bryan KS; ZOU, Bin; BOLLU, Venkatataiah; WO2014/78802; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts