Some common heterocyclic compound, 1735-88-2, name is 2-Cyano-N-(4-fluorophenyl)acetamide, molecular formula is C9H7FN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H7FN2O
A mixture of N-(4-fluorophenyl)cyanoacctamide (1 equiv.), hydroxylamine hydrochloride (2 equiv.) and tricthylamine (2 equiv.) in DMF was heated to 50-60nC for 4 h th«n diluted with water and the product filtered off and dried.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1735-88-2, its application will become more common.
Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; WO2008/70891; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts