Application of 50846-36-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50846-36-1 as follows.
200 g of 2-amino-2-methylpropionitrile hydrochloride was added to a 3. 0 L round bottom flask and 1.5 g of methanol and 167 g of triethylamine were added to the reaction flask again, and the reaction solution was cooled to 10 And then 325 g of di-tert-butyl dicarbonate was added dropwise to the reaction solution at room temperature for 2. 0 h, and the temperature was raised to reflux 3. Oh; TLC detection, the reaction was complete and concentrated under reduced pressure. The remaining solid was dissolved with ethyl acetate, The aqueous layer was washed twice with ethyl acetate and the combined organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 190 g.
According to the analysis of related databases, 50846-36-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nanjing wedo Pharmaceutical Co. Ltd.; Bao, jin yuan; song, zhi chun; Jiang, yuwei; Zhang, xiaoqing; (5 pag.)CN104016885; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts