Adding a certain compound to certain chemical reactions, such as: 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 654-70-6, name: 4-Cyano-3-trifluoromethylaniline
At room temperature, 1 ml of thiophosgene is added to 22 ml of water to form a suspension.Then 2.23 g of 4-amino-2-trifluoromethylbenzonitrile was added dropwise to the above solution.The dropwise addition time was 20 minutes, and after completion of the dropwise addition, stirring was continued for 1 hour at room temperature. After completion of the reaction, the reaction solution was extracted with 2 x 20 ml of methylene chloride. The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure (about 0.4 mmHg) to give 2.72 g of the title compound,Brown oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Cyano-3-trifluoromethylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Beijing Haimeiyuan Pharmaceutical Technology Co., Ltd.; Wang Yingzhao; Di Wei; Liu Yanling; (34 pag.)CN104341351; (2018); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts