Some common heterocyclic compound, 50397-74-5, name is 4-Amino-3-bromobenzonitrile, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H5BrN2
4 – Amino -3 – bromoxynil (4 – Amino – 3 – bromobenzonitrile) 50.0g (253.76 mmol), 4 – bromobenzoyl chloride (4 – Bromobenzoyl chloride) 55.7g (253.76 mmol) 500 ml and pyridine (Pyridine) 12 hoursAfter completion of the reaction, the solvent was distilled under reduced pressure. A slightly yellow solid compound (intermediate (5)) 75.6g (=unitz ) was obtained using diisopropyl ether (IPE) to carry out the solid-state reaction with diisopropyl ether (IPE 78.3%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 50397-74-5, its application will become more common.
Reference:
Patent; Co., Ltd. Leputuo; Wu Weizhen; Han Jiazhong; Jin Huizhen; Jin Xiane; Jin Kuili; Ren Zhezhu; Xi Wenji; Gao Bingzhu; (46 pag.)CN109988119; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts