Related Products of 7357-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7357-70-2, name is 2-Cyanothioacetamide, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: A mixture of the required acetophenones (0.001 mol),the appropriate aromatic aldehydes (0.001 mol), cyanothioacetamide(0.1 g, 0.001 mol) and ammonium acetate (0.62 g,0.008 mol) in n-butanol (10 mL) is irradiated at 150C for20 min in the microwave oven. After the reaction mixture iscooled to room temperature, the reaction mixture is dilutedwith 10 mL diethyl ether and the separated solid is filtered,dried and crystallized from ethanol to afford compounds 4-10.1,2-Dihydro-6-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-2-thioxopyridine-3-carbonitrile (4)Yellow powder, yield: 0.35g (87%), mp: 294-296C. IR(KBr, cm-1): 3421 (NH), 3066 (CH-aromatic), 2843 (CHaliphatic),2222 (CN), 1136 (C=S). 1H-NMR (400 MHz, dimethylsulfoxide (DMSO)-d6), delta ppm: 3.73 (s, 3H, OCH3),3.85 (s, 3H, OCH3), 3.88 (s, 6H, 2OCH3), 6.88 (s, 1H, Ar-H),7.13 (d, 2H, J=7.5 Hz, Ar-H), 7.20 (s, 2H, Ar-H), 7.72 (d, 2H,J=7.7 Hz, Ar-H), 12.53 (s, 1H, NH, D2O exchangeable).13CNMR(100 MHz, DMSO-d6), delta ppm: 55.9, 56.2 (2C), 56.7,97.7, 102.3, 105.8 (2C), 114.6 (2C), 117.4, 128.6, 129.5, 130.5(2C), 140.4, 153.5 (2C), 155.9, 161.5, 167, 169. Anal. Calcd for:C22H20N2O4S (408.47): C, 64.69; H, 4.94; N, 6.86. Found: C,64.93; H, 5.07; N, 7.04.
The chemical industry reduces the impact on the environment during synthesis 2-Cyanothioacetamide. I believe this compound will play a more active role in future production and life.
Reference:
Article; Elhameid, Mohammed K. Abd; Ryad, Noha; My, Al-Shorbagy; Mohammed, Manal R.; Ismail, Mohammed M.; El Meligie, Salwa; Chemical and Pharmaceutical Bulletin; vol. 66; 10; (2018); p. 939 – 952;,
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