Electric Literature of 1080-74-6, These common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (2 g, 10.30 mmol, M = 194.19 g/mol) andfurfural (0.99 g, 0.85 mL, 10.30 mmol, M = 96.08 g/mol, d = 1.16) were dissolved in ethanol (50 mL)and the solution was heated at 80 C for 5 min. An orange precipitate formed. After cooling, it wasfiltered off, washed several times with ethanol, then pentane and dried under vacuum (2.33 g, 83%yield, orange solid).
The synthetic route of 1080-74-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bonardi, Aude-Heloise; Dumur, Frederic; Duval, Sylvain; Gigmes, Didier; Lalevee, Jacques; Noirbent, Guillaume; Xu, Yangyang; Molecules; vol. 25; 10; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts