Adding a certain compound to certain chemical reactions, such as: 22364-68-7, name is 2-(o-Tolyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22364-68-7, Quality Control of 2-(o-Tolyl)acetonitrile
General procedure: sodiumazide (1.5 mmol) was added to a magnetically stirred solution of nitrile 1a(1 mmol) in anhydrous DMF and the CAN (10 mmol %) was added. The reactionmixture was constantly stirred for another 6 h at 110 C under nitrogenatmosphere. After the completion of reaction as seen by TLC, the reactionmixture was brought to room temperature and the solvent was evaporatedunder vacuum. The crude thus obtained, was dissolved in ethyl acetate (20 mL)and solution was washed with acidified water (4 M HCl, 15 mL) twice.Separated organic layer was washed with brine solution dried overanhydrous Na2SO4, and solvent was removed under high vacuum to obtaintetrazole 1b as a white crystalline solid in 97% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(o-Tolyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kumar, Satyanand; Dubey, Shristy; Saxena, Nisha; Awasthi, Satish Kumar; Tetrahedron Letters; vol. 55; 44; (2014); p. 6034 – 6038;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts