Adding a certain compound to certain chemical reactions, such as: 36282-26-5, name is 2-Bromo-4-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36282-26-5, Formula: C7H3BrFN
Sodium hydride (60% suspension in mineral oil, 0.031 g, 0.77 mmol) is added to a solution of 2-bromo-4- fluorobenzonit?le (0.128 g, 0.64 mmol) and 3,4,5- t?methoxyphaneyl acetic acid methyl ester (0.1854 g, 0.77 mmol) in DMF (2 mL) . The reaction mixture is stirred at 60 0C for 3 h. After addition of water (3 mL) , the aqueous phase is extracted with EtOAc (3 x) . The combined organic layers are washed with brine, dried over MgSO4, and evaporated to dryness. The residue is purified by column chromatography (SiO2, 20%-50% EtOAc/hexanes) to yield 0.1363 g (51%) of (3-Bromo-4-cyano- phenyl) – (3, 4 , 5-trimethoxy-phenyl) -acetic acid methyl ester. LC/MS Calculated for Ci9Hi8BrNO5: m/z = 420.26. Found: m/z = 421.8 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SERENEX, INC.; WO2008/24963; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts