Synthetic Route of 64248-62-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64248-62-0 name is 3,4-Difluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3,4-difluorobenzonitrile (2.500 g, 17.973 mmol), titanium isoproxoxide (6.917 mL, 23.364 mmol) and ethylmagnesium bromide (1.00 M solution in THF, 41.337 mL, 41.337 mmol) was dissolved in 2-methoxy-2-methylpropane (MTBE, 30 mL), at -20 C and the mixture was stirred at the same temperature for 30 minutes. To the reaction mixture borontrifluoride diethyl etherate (4.436 mL, 35.945 mmol) was added and further stirring at room temperature for 3 hours, then, at room temperature, sodium hydroxide (3.00 M solution in water, 17.973 mL, 53.918 mmol) was added and the reaction was terminated by stirring for 30 minutes. The reaction mixture was filtered through a pad of celite to remove the solid. Water was poured into the filtrate and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 40 g cartridge; methanol / dichloromethane = 5% to 30%) and concentrated to give the title compound (0.822 g, 27.0%) as a light yellow liquid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,4-Difluorobenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts