Some common heterocyclic compound, 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, molecular formula is C8H5F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Cyano-3-trifluoromethylaniline
At 0 C, liquid bromine (21.68 g, 135.66 mmol) was slowly added dropwise to a solution of Compound 36a (25.00 g, 134.31 mmol) in methanol (200 mL). After the resulting reaction mixture was further stirred for 0.5 hr, a saturated solution of sodium thiosulfate (200 mL) was added to the reaction system at 0 C to quench the reaction. The resulting mixture was diluted with water (1000 mL), and filtered. The filter cake was washed with water (200 mL×3), and dried under reduced pressure to give Compound 36b (34.30 g). 1H NMR (400 MHz, DMSO-d6) delta8.14 (s, 1H), 7.20 (s, 1H), 6.90 (brs, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 654-70-6, its application will become more common.
Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; CHEN, Bin; YAO, Yuanshan; CHEN, Yuan; LI, Ao; XU, Ran; HUANG, Zhensheng; TIAN, Dongdong; LI, Hongwei; YANG, Chengshuai; LI, Jian; CHEN, Shuhui; (69 pag.)EP3489235; (2019); A1;,
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