In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Chemical Modifications of Gold Surfaces with Basic Groups and a Fluorescent Nanoparticle Adhesion Assay To Determine Their Surface pKa, published in 2019-06-04, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Category: nitriles-buliding-blocks.
Purpose For pharmaceutical, biol. and biomedical applications the functionalization of gold surfaces with pH-sensitive groups has great potential. The aim of this work was to modify gold surfaces with pH-sensitive groups and to determine the pKa of the modified gold surfaces using a fluorescent nanoparticle adhesion assay. Methods To introduce pH-sensitive groups onto gold surfaces, we modified gold-coated silicon slides with four different bases: 4-mercaptopyridine (4-MP), 4-pyridylethylmercaptan (4-PEM), 4-aminothiophenol (4-ATP), and 2-mercaptoethylamine (2-MEA). To screen whether the modifications were successful, the binding of neg. charged fluorescently-labeled nanoparticles to the pos. charged surfaces was visualized by fluorescence microscopy and at. force microscopy. Next, the pKa of the modified surfaces was determined by quantifying the pH-dependent adhesion of the fluorescently-labeled nanoparticles with fluorescence spectroscopy. Results Fluorescence microscopy showed that the gold surfaces were successfully modified with the four different basic mols. Moreover, fluorescence spectroscopy revealed that fluorescently-labeled neg. charged nanoparticles bound onto gold surfaces that were modified with one of the four bases in a pH-dependent manner. By quantifying the adsorption of neg. charged fluorescently-labeled nanoparticles onto the functionalized gold surfaces and using the Henderson-Hasselbalch equation, the pKa of these surfaces was determined to be 3.7 ± 0.1 (4-MP), 5.0 ± 0.1 (4-PEM), 5.4 ± 0.1 (4-ATP), and 7.4 ± 0.3 (2-MEA). Conclusion We successfully functionalized gold surfaces with four different basic mols., yielding modified surfaces with different pKa values as determined with a fluorescent nanoparticle adhesion assay.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts