Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Product Details of C9H6BrNO.
Das, Sumit;Singh, Bhagat;Fadikar, Pulak;Barman, Piyali Deb;Paira, Rupankar research published 《 Application of recyclable base-washed graphene oxide for one-pot conversion of 2-aminopyridines into 3-iodo-imidazo[1,2-a]pyridines at room temperature in water》, the research content is summarized as follows. A green synthetic protocol for cyclization of 2-aminopyridines I (R = H, 3-Me, 4-Me, 4-Cl, 4-Br, 5-Cl) with 2-bromoacetophenones R1C(O)CH2Br (R1 = 4-bromophenyl, 3-tert-butylphenyl, naphthalen-2-yl, etc.) to prepare imidazo[1,2-a]pyridines, followed by their successive iodination in one-pot manner to give II (R2 = H, 7-Me, 8-Me, 6-Cl, 7-Cl, 7-Br), employing base-washed graphene oxide as the catalyst, in water has been described. The current approach has offered to carry out the reaction in water medium at room temperature and the base-washed graphene oxide catalyst has provided excellent product yield (upto 81%) and can also be recycled effortlessly upto 5 catalytic cycles, through a simple base-wash protocol. The catalyst is an inexpensive, environmentally benign, green, and heterogeneous platform and has been characterized by IR, Raman, SEM and TEM studies.
Product Details of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts