Jiang, Shuai; Cao, Wen-Bin; Xu, Xiao-Ping; Ji, Shun-Jun published the artcile< Cobalt-Catalyzed Isocyanide-Based Three-Component Cascade for the Synthesis of Quinazolines>, Related Products of 38487-85-3, the main research area is quinazoline preparation; arylisocyanide arylamine azide three component tandem heterocyclization cobalt catalyst.
A Co-catalyzed cyclization reaction of isocyanides 1-NC-4-R-5-R1C6H2CN (R = H, Me, F, OMe, etc.; R1 = H, OMe, Br), azides R2S(O)ON3 (R2 = n-Pr, Ph, cyclohexyl, thiophen-2-yl, etc.), and amines R3NH2 (R3 = n- Bu, Ph, 1-methyl-1H-indol-5-yl, etc.) to access quinazoline derivatives I and II (R4 = H, n-Bu, t-Bu, 4-methylphenyl) was described. This protocol features a high atom economy, mild reaction conditions, excellent yields, and a broad substrate scope. This cascade reaction involved three or four C-N bonds and the formation of one or two rings. The quinazolin-4(H)-imines I and II obtained are proven to be versatile intermediates for further valuable transformations. It was also found that the cobalt catalyst could be isolated from the reaction mixture and reused.
Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Related Products of 38487-85-3.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts