In 2018,Scheidt, Felix; Schaefer, Michael; Sarie, Jerome C.; Daniliuc, Constantin G.; Molloy, John J.; Gilmour, Ryan published 《Enantioselective, Catalytic Vicinal Difluorination of Alkenes》.Angewandte Chemie, International Edition published the findings.SDS of cas: 105942-08-3 The information in the text is summarized as follows:
An efficient method was developed for the synthesis of 1,2-difluoroethyl arenes ArCH(F)CH2F [Ar = 3-CNC6H4, 4-O2NC6H4, 2-SO2MeC6H4, etc.] via enantioselective II/IIII catalytic vicinal difluorination of terminal alkenes using novel C2-sym. resorcinol derivative Catalyst turnover via in situ generation of an ArIIIIF2 species was enabled by Selectfluor oxidation and addition of an inexpensive HF-amine complex. The HF:amine ratio employed in this process provided a handle for regioselective orthogonality as a function of Bronsted acidity. Selectivity reversal from the 1,1-difluorination pathway (geminal) to the desired 1,2-difluorination (vicinal) was disclosed (>20:1 in both directions). An achiral variant of the reaction was also presented using p-iodotoluene (up to >95 % yield). In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3SDS of cas: 105942-08-3)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.SDS of cas: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts