In 2019,European Journal of Medicinal Chemistry included an article by Pan, Xiaoyan; Liang, Liyuan; Sun, Ying; Si, Ru; Zhang, Qingqing; Wang, Jin; Fu, Jia; Zhang, Junjie; Zhang, Jie. Electric Literature of C7H3BrFN. The article was titled 《Discovery of novel Bcr-AblT315I inhibitors with flexible linker. part 1: confirmation optimization of phenyl-1H-indazol-3-amine as hinge binding moiety》. The information in the text is summarized as follows:
As a continuation to our research, a series of novel Bcr-Abl inhibitors incorporated with 6-phenyl-1H-indazol-3-amine as hinge binding moiety (HBM) were developed based on confirmation anal. Biol. results indicated that these compounds exhibited an enhanced inhibition against Bcr-AblWT and Bcr-AblT315I in kinases assays, along with improved anti-proliferative activities in K562 cell assays. In particular, compound Y9(I) displayed comparable potency with that of imatinib. It potently inhibited Bcr-AblWT and Bcr-AblT315I kinases with IC50 of 0.043 μM and 0.17 μM, resp. Furthermore,(I) inhibited the proliferation of K562 and K562R cells with IC50 of 1.65 μM and 5.42 μM, resp. Therefore, 6-phenyl-1H-indazol-3amine as HBM, combined with flexible linker, is a successful strategy contribute to research on T315I mutant resistance, and I could be served as a starting point for further optimization. After reading the article, we found that the author used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Electric Literature of C7H3BrFN)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Electric Literature of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts