《Diversity oriented multi-component reaction (DOS-MCR) approach to access natural product analogues: regio- and chemo-selective synthesis of polyheterocyclic scaffolds via one-pot cascade reactions》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Palanivel, Lakshmanan; Gnanasambandam, Vasuki. Quality Control of 3-Oxo-3-phenylpropanenitrile The article mentions the following:
Skeletally diverse and complex aza-cyclopenta(cd)diindenes, pyrrolo(3,4-d)pyridine-13-carboxamides, furo-pyrrolo(1,2-a)imidazole-4-carboxamidesand furo(2,3-b)furans were accessed via one-pot three-component cascade Knoevenagel condensation/Michael addition/Paal-Knorr cyclization of glyoxals and various nitriles. This protocol was metal free, had a good substrate scope and afforded products with good to excellent yields and regio- and chemo-selectivity. The heterocyclic skeletons obtained in this study mimicked natural products such as eupolauramine, gracilamine and presilphiperfolanol. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Quality Control of 3-Oxo-3-phenylpropanenitrile) was used in this study.
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Quality Control of 3-Oxo-3-phenylpropanenitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts