Name: 4-BromobenzonitrileIn 2020 ,《Regioselective Hydroalkylation and Arylalkylation of Alkynes by Photoredox/Nickel Dual Catalysis: Application and Mechanism》 was published in Angewandte Chemie, International Edition. The article was written by Yue, Huifeng; Zhu, Chen; Kancherla, Rajesh; Liu, Fangying; Rueping, Magnus. The article contains the following contents:
Alkynes are an important class of organic mols. due to their utility as versatile building blocks in synthesis. Although efforts have been devoted to the difunctionalization of alkynes, general and practical strategies for the direct hydroalkylation and alkylarylation of terminal alkynes under mild reaction conditions are less explored. Herein, a photoredox/nickel dual-catalyzed anti-Markovnikov-type hydroalkylation of terminal alkynes as well as a one-pot arylalkylation of alkynes with alkyl carboxylic acids and aryl bromides via a three-component cross-coupling has been discussed. The results indicate that the transformations proceed via a new mechanism involving a single-electron transfer with subsequent energy-transfer activation pathways. Moreover, steady-state and time-resolved fluorescence-spectroscopy measurements, d. functional theory (DFT) calculations, and wavefunction anal. have been performed to give an insight into the catalytic cycle. In addition to this study using 4-Bromobenzonitrile, there are many other studies that have used 4-Bromobenzonitrile(cas: 623-00-7Name: 4-Bromobenzonitrile) was used in this study.
4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Name: 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts