Reference of 4-Cyanobenzyl bromideIn 2019 ,《A Facile Synthesis of Substituted 2-(5-(Benzylthio)-1,3,4-oxadiazol-2-yl)pyrazine Using Microwave Irradiation and Conventional Method with Antioxidant and Anticancer Activities》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Patil, Sanjeev R.; Sarkate, Aniket P.; Karnik, Kshipra S.; Arsondkar, Ashish; Patil, Vrushali; Sangshetti, Jaiprakash N.; Bobade, Anil S.; Shinde, Devanand B.. The article conveys some information:
A series of novel substituted 2-(5-(benzylthio)-1,3,4-oxadiazol-2-yl)pyrazine derivatives I (X = 2,4-Cl2, 3-MeO, 4-NO2, etc.) was synthesized under microwave irradiation and conventional conditions with less reaction time with good to excellent yields. All the synthesized compounds I were screened for antioxidant and anticancer activities. Out of the 14 prepared derivatives, compounds I (X = H, 3-F) were most potent and active with antioxidant and anticancer activities, resp. Also, the developed technique was simple, easy, and less time consuming. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)
4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Reference of 4-Cyanobenzyl bromide
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts