Ibis, Kubra; Nalbat, Esra; Caliskan, Burcu; Kahraman, Deniz Cansen; Cetin-Atalay, Rengul; Banoglu, Erden published an article in 2021. The article was titled 《Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells》, and you may find the article in European Journal of Medicinal Chemistry.Product Details of 17201-43-3 The information in the text is summarized as follows:
A series of isoxazole-piperazine analogs I (R = 2-Me, 4-Cl, 3-CN, etc.) and II (R1 = 2-Me, 3-Me, 2-F, 3-F; R2 = ((4-(4-(trifluoromethyl)benzyl)piperazin-1-yl), (4-(furan-2-carbonyl)piperazin-1-yl), (1-benzylpiperidin-4-yl)amino), etc.) were prepared, screened for their antiproliferative potential against hepatocellular carcinoma (HCC; Huh7/Mahlavu) and breast (MCF-7) cancer cells and demonstrated potent to moderate cytotoxicity with IC50 values in the range of 0.09-11.7μM. Further biol. studies with I (R1 = H) and II (R = 3-F; X = (4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)) in HCC cells have shown that both compounds induced G1 or G2/M arrests resulting in apoptotic cell death. Subsequent anal. of proteins involved in cell cycle progression as well as proliferation of HCC cells revealed that these 2 compounds may affect cellular survival pathways differently depending on the mutation profiles of cells (p53 and PTEN) and epidermal/mesenchymal characteristics. Lastly, authors have demonstrated the potential anti-stemness properties of these compounds was demonstrated in which the proportion of liver CSCs in Huh7 cells (CD133+/EpCAM+) were significantly reduced by I (R1 = H) and II (R = 3-F; X = (4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)). Furthermore, both compounds caused a significant reduction in expression of stemness markers, NANOG or OCT4 proteins, in Mahlavu and Huh7 cells, as well as resulted in a decreased sphere formation capacity in Huh7 cells.4-Cyanobenzyl bromide(cas: 17201-43-3Product Details of 17201-43-3) was used in this study.
4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Product Details of 17201-43-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts