In 2018,Cao, Qun; Howard, Joseph L.; Wheatley, Emilie; Browne, Duncan L. published 《Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling》.Angewandte Chemie, International Edition published the findings.SDS of cas: 105942-08-3 The information in the text is summarized as follows:
A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochem. methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochem. methods. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3SDS of cas: 105942-08-3) was used in this study.
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.SDS of cas: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts