Application In Synthesis of 4-Cyanobenzyl bromideIn 2020 ,《6-Nitro-1-benzylquinolones exhibiting specific antitubercular activity》 was published in Chemical Biology & Drug Design. The article was written by Beteck, Richard M.; Jordaan, Audrey; Swart, Tarryn; Van Der Kooy, Frank; Warner, Digby F.; Hoppe, Heinrich C.; Legoabe, Lesetja J.. The article contains the following contents:
In this study, we synthesized novel nitro quinolone-based compounds and tested them in vitro against a panel of Gram-pos. and Gram-neg. pathogens including Mycobacterium tuberculosis (MTB), Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumonia, Staphylococcus aureus, and Escherichia coli for antibacterial activities and also against HeLa cells for overt cytotoxicity. Compound I was identified as a non-toxic, potent hit with selective activity (MIC90 < 0.24μM) against MTB. I, however, showed no activity against DprE1 mutant, suggesting DprE1 as the likely target for this compound class. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)
4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Application In Synthesis of 4-Cyanobenzyl bromide
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts