《Biaryl Cross-Coupling Enabled by Photo-Induced Electron Transfer》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Hayashi, Hirohito; Wang, Bin; Wu, Xiangyang; Teo, Shi Jie; Kaga, Atsushi; Watanabe, Kohei; Takita, Ryo; Yeow, Edwin K. L.; Chiba, Shunsuke. Product Details of 105942-08-3 The article mentions the following:
A protocol for aryl cross-coupling of electron-deficient aryl halides ArX (Ar = 3-formylphenyl, 4-formylfuran-2-yl, 2-(methoxycarbonyl)pyrimidin-5-yl, etc.; X = Br, Cl) with electron-rich (hetero)arenes Ar1H (Ar1 = Ph, 1-methyl-1H-pyrrol-2-yl, pyrazin-2-yl, etc.) that is driven solely by violet light was reported. This process takes advantage of formation of photo-excited state of electron-deficient aryl halides, that are reduced by electron-rich (hetero)arenes to form a pair of aryl anion and cation radicals. The resulting aryl anion radicals of aryl halides undergo mesolysis of the carbon-halogen bond to generate aryl radicals, that are coupled most likely with aryl cation radicals to afford functionalized biaryls ArAr1. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3) was used in this study.
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts