Application of 17201-43-3In 2020 ,《Synthesis, molecular docking simulation, and biological evaluation studies of novel amide and ether conjugates of 2,3-diaryl-1,3-thiazolidin-4-ones》 was published in Journal of Heterocyclic Chemistry. The article was written by Daipule, Komal; Goud, Nerella Sridhar; Sethi, Aaftaab; Gurrapu, Swapna; Mamidala, Estari; Alvala, Mallika. The article contains the following contents:
To develop potent lead mols. as a novel class of reverse transcriptase (RT) inhibitors, amide and ether conjugates of 2,3-diaryl-1,3-thiazolidin-4-ones I (R1 = Ph, 2-BrC6H4, 2,3-Me2C6H3, 2-pyridyl, etc.) and II (R2 = H2C:CHCH2, HCCCH2, PhCH2, 3-ClC6H4CH2, etc.) were synthesized. The compounds II (R2 = PhCH2) and II (R2 = 4-FC6H4CH2) exhibited IC50 values of 0.21113 ± 0.013μM and 12.6804 ± 0.062μM resp. from the in-vitro human immunodeficiency virus type 1 (HIV-1) RT assay. None of the compounds showed toxicity towards peripheral blood mononuclear cells (PBMC). Structure-activity relationship (SAR) studies were performed for the synthesized compounds I and II in order to estimate the effect of the substitution pattern on the RT inhibition potency. In silico docking studies revealed that two or more interactions were necessary for significant activity. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)
4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Application of 17201-43-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts