COA of Formula: C7H4FNIn 2019 ,《Selective synthesis of secondary amines from nitriles by a user-friendly cobalt catalyst》 was published in Advanced Synthesis & Catalysis. The article was written by Sharma, Dipesh M.; Punji, Benudhar. The article contains the following contents:
A simple, inexpensive and user-friendly cobalt-catalyzed method for the selective and practical synthesis of sym. and unsym. secondary amines RCH2NR1R2 [R = Pr, Ph, Bn, etc.; R1 = H, Me, Et; R2 = N-morpholinyl, Ph, 4-pyridyl, etc.] was developed via reductive amination of nitriles. The use of (xantphos)CoCl2 and ammonia borane (NH3-BH3) combination afforded the selective reduction of nitriles to sym. secondary amines, whereas the employment of (xantphos)CoCl2 and dimethylamine borane along with external amines produced unsym. secondary amines and tertiary amines. The reaction tolerated diverse functionalities, such as alkyl, alkyl ether, halides and heteroarenes. The results came from multiple reactions, including the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1COA of Formula: C7H4FN)
4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.COA of Formula: C7H4FN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts