In 2012,Yeh, Vince S. C.; Beno, David W. A.; Brodjian, Sevan; Brune, Michael E.; Cullen, Steven C.; Dayton, Brian D.; Dhaon, Madhup K.; Falls, Hugh D.; Gao, Ju; Grihalde, Nelson; Hajduk, Philip; Hansen, T. Matthew; Judd, Andrew S.; King, Andrew J.; Klix, Russel C.; Larson, Kelly J.; Lau, Yau Y.; Marsh, Kennan C.; Mittelstadt, Scott W.; Plata, Dan; Rozema, Michael J.; Segreti, Jason A.; Stoner, Eric J.; Voorbach, Martin J.; Wang, Xiaojun; Xin, Xili; Zhao, Gang; Collins, Christine A.; Cox, Bryan F.; Reilly, Regina M.; Kym, Philip R.; Souers, Andrew J. published 《Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of Acyl-CoA: Diacylglycerol acyltransferase 1》.Journal of Medicinal Chemistry published the findings.SDS of cas: 31938-07-5 The information in the text is summarized as follows:
A high-throughput screen against human DGAT-1 led to the identification of a core structure that was subsequently optimized to afford the potent, selective, and orally bioavailable compound (I). Oral administration at doses ≥0.03 mg/kg significantly reduced postprandial triglycerides in mice following an oral lipid challenge. Further assessment in both acute and chronic safety pharmacol. and toxicol. studies demonstrated a clean profile up to high plasma levels, thus culminating in the nomination of I as clin. candidate ABT-046. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.SDS of cas: 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts