As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127946-77-4 name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 127946-77-4
Step 10: N2-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]-N1-(1-cyanocyclopropyl)-4-fluoro-L- leucinamide. Diisopropylethylamine (4.2 mL) was added to a 0 C suspension of the acid (1.5 g) from Step 9, 1-amino-1-cyclopropanecarbonitrile hydrochloride (1. 18 g), O-(7-azabenzotriazol-1-yl)-N, N, N’, N’-tetramethyluronium hexafluorophosphate (1.94 g) and DIMETHYLFORMAMIDE (5 mL) and the mixture was reacted at room temperature for 48 hrs. It was then poured on ice and dilute aqueous ammonium chloride. The mixture was extracted with ethyl acetate and ether (1: 1) and the combined organic layers were washed with pH 3 dilute NA2HP04 and brine. The solvents were evaporated to dryness and the residue was purified by chromatography on SI02 using ethyl acetate and hexanes (1: 2) to yield N2-[(1S)- 1- (4-BROMOPHENYL)-2, 2, 2-TRIFLUOROETHYL]-N -(L-CYANOCYCLOPROPYL)-4-FLUORO-L-LEUCINAMIDE in a sufficient purity state for the next step. 1H NMR (CD3 COCD3) No. 8.15 (1H, NH), 7.6 (2H, m), 7.45 (2H, m), 4.35-4. 45 (1H, m), 3.45-3. 55 (1H, M), 1.9-2. 1 (2H, m), 1.75-1. 85 (1H, NH), 1.35-1. 55 (8H, M), 1. 1-1. 15 (1H, M), 0.95-1. 05 (1H, M).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; MERCK FROSST CANADA & CO.; WO2005/21487; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts