In 2019,Asian Journal of Organic Chemistry included an article by Kim, Jihyeon; Golime, Gangadhararao; Kim, Hun Young; Oh, Kyungsoo. Safety of 4-Fluorobenzonitrile. The article was titled 《Copper(II)-Catalyzed Aerobic Oxidation of Amines: Divergent Reaction Pathways by Solvent Control to Imines and Nitriles》. The information in the text is summarized as follows:
The Cu(OAc)2-catalyzed aerobic oxidations of amines to imines RR1CH=NR2 [R = H, Me; R1 = Ph, 4-MeC6H4, 2-thienyl, etc.; R2 = cyclohexyl, Ph, Bn, etc.] and nitriles R3CN [R3 = n-heptyl, Ph, 2-thienyl, etc.] were identified under solvent control conditions and in the presence of mol. oxygen. By modulating the aerobic oxidation pathways of Cu(OAc)2 catalyst in different reaction solvents, the selective formations of homo-coupled imines, cross-coupled imines and nitriles were achieved from amine derivatives In the experiment, the researchers used 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)
4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Safety of 4-Fluorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts