Rzhevskiy, Sergey A.; Topchiy, Maxim A.; Bogachev, Vasilii N.; Minaeva, Lidiya I.; Cherkashchenko, Ilia R.; Lavrov, Konstantin V.; Sterligov, Grigorii K.; Nechaev, Mikhail S.; Asachenko, Andrey F. published their research in Mendeleev Communications in 2021. The article was titled 《Solvent-free palladium-catalyzed C-O cross-coupling of aryl bromides with phenols》.Product Details of 2042-37-7 The article contains the following contents:
A new solvent-free procedure for C-O cross-coupling between phenols ArOH (Ar = Ph, 4-chlorophenyl, 2-isopropylphenyl, etc.) and aryl bromides Ar1Br (Ar1 = 4-methylphenyl, 2-cyanophenyl, 3,5-bis(trifluoromethyl)phenyl, etc.) comprising of Pd2(dba)3/ButBrettPhos catalytic system is efficient for substrates bearing donor or acceptor, as well as bulky substituents.2-Bromobenzonitrile(cas: 2042-37-7Product Details of 2042-37-7) was used in this study.
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Product Details of 2042-37-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts