《Synthesis and Characterization of Ultrapure HKUST-1 MOFs as Reusable Heterogeneous Catalysts for the Green Synthesis of Tetrazole Derivatives》 was published in ChemistrySelect in 2020. These research results belong to Kal-Koshvandi, Afsaneh Taheri; Maleki, Ali; Tarlani, Aliakbar; Soroush, Maral Rahim. Recommanded Product: 4-Fluorobenzonitrile The article mentions the following:
An ultrapure HKUST-1 MOFs synthesized through a precised methodol. as a heterogeneous catalyst for a green approach to the synthesis of tetrazole derivatives via two-, three-, and four-component reactions in milder reaction conditions was presented. Various preparation methods to produce HKUST-1 such as microwave irradiation, reflux, hydrothermal technique, and ultrasonication was precisely compared and it was proved that the best result was obtained during the hydrothermal technique. This was the first design, preparation, characterization and application in the present of HKUST-1 MOFs to the synthesis of the biol. and pharmaceutically important tetrazole compounds in green conditions. Moreover, plausible mechanisms of reactions was suggested for the catalytic activity of the presented catalyst. The catalyst was characterized by various techniques such as FT-IR, SEM, EDX, and XRD. Addnl., HKUST-1 was recoverable as well as reusable without any significant loss of its activity, which strongly supports the heterogeneous nature of the catalyyst. This novel catalysis protocol offered several advantages such as eco-friendly conditions, lower reaction time, milder reaction conditions, excellent catalytic activity and an easy separation of the catalyst make it a good heterogeneous system. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile)
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Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts