In 2003,Langer, Peter; Anders, Joachim T.; Weisz, Klaus; Jaehnchen, Judith published 《Efficient synthesis of 2-alkylidene-3-iminoindoles, indolo[1,2-b]isoquinolin-5-ones, δ-carbolines, and indirubines by domino and sequential reactions of functionalized nitriles》.Chemistry – A European Journal published the findings.Application of 31938-07-5 The information in the text is summarized as follows:
The sodium hydride mediated cyclization of arylacetonitriles with oxalic acid bis(imidoyl) dichlorides, aza-analogs of oxalyl chloride, afforded functionalized 2-alkylidene-3-iminoindoles with very good regio- and E/Z selectivity. Excellent chemoselectivities were observed for functionalized substrates. Based on these results a domino “”cyclization-lactamization”” reaction of bis(imidoyl) chlorides with Me 2-(cyanomethyl)benzoate was developed. This process allowed a convenient one-pot synthesis of indolo[1,2-b]isoquinolin-5-ones related to tryptanthrin. A new and convenient synthesis of δ-carbolines by intramol. electrocyclization-elimination reactions of 2-alkylidene-3-iminoindoles was developed. It was shown that δ-carbolines selectively bind to triplex or duplex DNA (intercalation). Indirubine analogs were prepared by deprotection and lactonization of functionalized 2-alkylidene-3-iminoindoles. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application of 31938-07-5)
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Application of 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts