《Practical Synthesis of (Z)-α,β-Unsaturated Nitriles via a One-Pot Sequential Hydroformylation/Knoevenagel Reaction》 was written by Jiang, Yanxin; Li, Chao; Tang, Songbai; Tao, Shaokun; Yuan, Maolin; Li, Ruixiang; Chen, Hua; Fu, Haiyan; Zheng, Xueli. Recommanded Product: 31938-07-5This research focused onunsaturated nitrile preparation; olefin alkyne one pot sequential hydroformylation Knoevenagel reaction. The article conveys some information:
Herein, the synthesis of (Z)-α,β-unsaturated nitriles by a sequential hydroformylation/Knoevenagel reaction has been first developed. A variety of crude α-olefins from Fischer-Tropsch synthesis, internal and special olefins, as well as alkynes could be transformed into value-added alkenyl nitriles (39 examples) up to 90% yield. Remarkably, compared with commonly used tedious multistep reactions, the one-pot protocol features cheap and easily available raw materials, excellent chemo-, regio-, and stereoselectivity, very mild reaction conditions, and easy scale-up production The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Recommanded Product: 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts