Garnes-Portoles, Francisco; Greco, Rossella; Oliver-Meseguer, Judit; Castellanos-Soriano, Jorge; Consuelo Jimenez, M.; Lopez-Haro, Miguel; Hernandez-Garrido, Juan Carlos; Boronat, Mercedes; Perez-Ruiz, Raul; Leyva-Perez, Antonio published an article in 2021. The article was titled 《Regioirregular and catalytic Mizoroki-Heck reactions》, and you may find the article in Nature Catalysis.Recommanded Product: 2-Bromobenzonitrile The information in the text is summarized as follows:
Here, the ligand-free, few-atom palladium clusters in solution catalyze the α-selective intramol. Mizoroki-Heck coupling of iodoaryl cinnamates, and mechanistic studies support the formation of a sterically encumbered cinnamate-palladium cluster intermediate was showed. Following this rationale, the α-selective intermol. coupling of aryl iodides with styrenes was also achieved with palladium clusters encapsulated within fine-tuned and sterically restricted zeolite cavities to produce 1,1-bisarylethylenes, which are further engaged with aryl halides by a metal-free photoredox-catalyzed coupling. These ligand-free methodologies significantly expand the chem. space of the Mizoroki-Heck coupling. The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Recommanded Product: 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts